Polarography of an acidic degradation product from cephalexin
L J Nuñez-Vergara1, J A Squella, M M Silva
1Department of Chemical Pharmacology and Physical Chemistry, Faculty of Chemical and Pharmacological Sciences, University of Chile, P.O. Box 233, Santiago, Chile.
Talanta
|February 1, 1982
Abstract:
2-Hydroxy-3-phenyl-6-methylpyrazine is identified as the product obtained by acidic degradation of cephalexin in the presence of formaldehyde. In 5M hydrochloric acid this product gives a well-defined reduction wave with a half-wave potential of -0.45 V vs. SCE. The wave is irreversible and diffusion-controlled. The diffusion current shows a linear relation with the cephalexin concentration and can be used for determination of cephalexin in plasma.
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