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Reliable Mechanochemistry: Protocols for Reproducible Outcomes of Neat and Liquid Assisted Ball-mill Grinding Experiments

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Solid-phase chemistry: Its principles and applications in clinical analysis.

A Zipp¹, W E Hornby

¹Ames Division, Miles Laboratories Inc., Elkhart, Indiana, U.S.A.

|October 1, 1984

Summary

This review covers the evolution of solid-phase reaction systems, including test papers and film systems, for quick clinical analysis in both lab and field settings.

Area of Science:

Clinical chemistry
Analytical chemistry
Biomedical engineering

Background:

Solid-phase reaction systems offer advantages for rapid diagnostic testing.
Traditional methods can be time-consuming and require specialized equipment.
The demand for point-of-care testing has driven innovation in this field.

Purpose of the Study:

To review the development of various solid-phase reaction systems.
To highlight their applications in clinical analysis.
To discuss their suitability for field and laboratory use.

Main Methods:

Review of literature on solid-phase reaction systems.
Categorization of systems based on format (test papers, impregnated-fibre, multi-layer film).
Analysis of their performance characteristics for clinical applications.

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Main Results:

Solid-phase systems have evolved significantly, offering improved sensitivity and speed.
Test papers, impregnated-fibre systems, and multi-layer film systems provide diverse options for different analytical needs.
These systems are effective for rapid detection and quantification in clinical settings.

Conclusions:

Solid-phase reaction systems are crucial for advancing rapid clinical diagnostics.
Continued development promises even more efficient and accessible testing solutions.
These technologies are vital for both laboratory-based and point-of-care testing.