Nafronyl ion-selective membrane electrodes and their use in pharmaceutical analysis

Area of Science:

• Analytical Chemistry
• Electrochemistry
• Pharmaceutical Analysis

Background:

• Accurate determination of active pharmaceutical ingredients (APIs) is crucial for drug quality control.
• Existing methods for nafronyl-drug quantification may lack speed or specificity.
• Potentiometric techniques offer a sensitive and rapid approach for drug analysis.

Purpose of the Study:

• To develop and validate a simple, rapid potentiometric method for nafronyl-drug determination.
• To assess the performance of nafronyl ion-selective electrodes in pharmaceutical preparations.
• To evaluate the method's accuracy and freedom from interference.

Main Methods:

• Development of nafronyl ion-selective membrane electrodes using specific ion-pair complexes.
• Utilizing electrodes with either nafronyl-dipicrylamine or nafronyl-dinonylnaphthalenesulphonic acid as electroactive materials.
• Potentiometric titration of nafronyl in pharmaceutical tablets with sodium tetraphenylborate.

Main Results:

• Both developed electrodes showed near-Nernstian responses to protonated-nafronyl activity over a wide concentration range (10^-2 to 10^-5 M).
• The method allowed for the determination of nafronyl in the milligram range with a relative standard deviation below 2.0%.
• No significant interference was observed from common tablet excipients, indicating high specificity.

Conclusions:

• The described potentiometric method is effective for the rapid and accurate determination of nafronyl-drugs in tablet formulations.
• Nafronyl ion-selective electrodes provide a reliable tool for pharmaceutical analysis.
• The method's simplicity and lack of interference make it suitable for routine quality control.