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X-ray Diffraction of Biological Samples01:10

X-ray Diffraction of Biological Samples

X-ray diffraction or XRD is an analytical tool that utilizes X-rays to study ordered structures such as crystalline organic and inorganic samples, polycrystalline materials, proteins, carbohydrates, and drugs.
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Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products
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X-ray diffraction data for six analgesics.

J E Kountourellis1, F A Underwood, P P Georgakopoulos

  • 1School of Physics, University of Bath, Bath, England.

Talanta
|July 1, 1986
PubMed
Summary
This summary is machine-generated.

Powder X-ray diffraction data were collected for six analgesic compounds. This study provides essential crystallographic information, including lattice spacings and line intensities, for these important pain-relieving medications.

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Area of Science:

  • Crystallography
  • Materials Science
  • Pharmacology

Background:

  • Understanding the crystalline structure of analgesics is crucial for drug formulation and efficacy.
  • X-ray diffraction (XRD) is a powerful technique for characterizing solid-state materials.

Purpose of the Study:

  • To obtain and present X-ray diffraction data for six common analgesic compounds.
  • To provide reference crystallographic data (lattice spacings and relative intensities) for these analgesics.

Main Methods:

  • Powder X-ray diffraction (PXRD) using a powder diffractometer.
  • Data analysis included tabulation of lattice spacings and relative intensities.
  • Results were validated using the Debye-Scherrer method.

Main Results:

  • Comprehensive X-ray diffraction data were successfully generated for six analgesics.
  • Lattice spacings and relative intensities for each compound were systematically recorded.
  • The obtained data were confirmed for accuracy and reproducibility.

Conclusions:

  • The study successfully characterized the crystal structures of six analgesics using powder XRD.
  • The generated data serve as a valuable reference for quality control and further research on these analgesics.
  • The findings underscore the utility of XRD in pharmaceutical analysis.