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Expression of fragile-X in a female fetus diagnosed after chorionic villus sampling
1Department of Clinical Genetics, Maternity Hospital, Birmingham, U.K.
Prenatal Diagnosis
|May 1, 1991
Abstract:
Study of different tissues of an aborted female fetus showed similar levels of fragile-X expression (6.3-9.2 per cent) and of early replication of the FRAXA-positive cells (50-66 per cent) in fetal tissues. Different culture media did not significantly affect either investigation. It is suggested that the distribution of X-inactivation in FRAXA-positive chorionic villus cells of a female fetus might indicate her future phenotype.