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Canine T-zone lymphoma: unique immunophenotypic features, outcome, and population characteristics
1Veterinary Clinical Sciences, University of Minnesota, St. Paul, MN.
Journal of Veterinary Internal Medicine
|March 25, 2014
Summary
Loss of CD45 antigen expression is a specific diagnostic marker for canine T-zone lymphoma (TZL), an indolent form of T-cell lymphoma (TCL). This finding aids in distinguishing TZL from aggressive TCL in dogs.
Area of Science:
- Veterinary Pathology
- Canine Oncology
- Immunophenotyping
Background:
- Canine T-cell lymphoma (TCL) is a diverse group of cancers.
- T-zone lymphoma (TZL) is an indolent subtype of canine TCL.
- Immunophenotyping is crucial for classifying TCL in dogs.
Purpose of the Study:
- To investigate if the loss of CD45 antigen expression is a specific diagnostic feature of TZL.
- To differentiate TZL from aggressive forms of canine TCL using immunophenotyping.
Main Methods:
- Flow cytometry was used for immunophenotyping of canine lymphoma samples.
- Lymph node biopsies from 35 dogs with TCL were classified by two pathologists.
- Outcome data and population characteristics were analyzed for dogs with TZL.
Main Results:
- All 20 cases with CD45- T-cell lymphoma were diagnosed as TZL.
- TZL cases exhibited a median survival of 637 days.
- 40% of TZL cases occurred in Golden Retrievers, with a median age of 10 years.
Conclusions:
- Loss of CD45 antigen expression is a unique immunophenotypic marker for canine TZL.
- Immunophenotyping can reliably diagnose TZL, distinguishing it from aggressive TCL.
