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Updated: Jun 28, 2026

On-chip Isotachophoresis for Separation of Ions and Purification of Nucleic Acids
Published on: March 2, 2012
Ionic equilibria in neutral amphiprotic solvents of low dielectric constant: Titration curves
Abstract:
Titration curves have been simulated for the titration of acids, bases and salts in neutral amphiprotic solvents such as isopropyl and tert-butyl alcohols. Ranges of pK values and acid concentrations have been examined. The incomplete dissociation of salts, which increases the acid or basic strength, has been found to be the major factor modifying the shape of the curve and the pH break. The theoretical predictions have been checked by titrating several series of acids and good agreement has been obtained between computed and experimental results.
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