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[Hypersensitivity reactions to ethylenediamine].

R Lleonart1, M Abadías, O Monés

  • 1Unidad de Alergia, Hospital de la Sta. Creu i Sant Pau, Barcelona.

Revista Clinica Espanola
|May 1, 1991
PubMed
Summary

Most allergic reactions to aminophylline are due to ethylenediamine hypersensitivity. Three asthmatic patients experienced adverse reactions, confirmed via skin testing for ethylenediamine sensitivity, and tolerated alternative theophylline drugs.

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Area of Science:

  • Allergy and Immunology
  • Pharmacology
  • Respiratory Medicine

Background:

  • Aminophylline, a common asthma medication, can trigger allergic reactions.
  • Ethylenediamine is a known excipient in some aminophylline formulations.
  • Hypersensitivity to excipients can complicate drug therapy.

Observation:

  • Three asthmatic patients presented with adverse reactions post-aminophylline administration.
  • Two patients experienced immediate allergic symptoms.
  • One patient developed generalized erythrodermia 24 hours after treatment.

Findings:

  • Skin testing confirmed ethylenediamine sensitivity in all three patients.
  • The allergic reactions were directly attributed to hypersensitivity to ethylenediamine.

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  • Patients could safely use theophylline preparations lacking ethylenediamine.

    • Implications:

    • Identifies ethylenediamine as the primary culprit in these aminophylline-induced allergic reactions.
    • Highlights the importance of considering excipient hypersensitivity in drug reactions.
    • Suggests alternative theophylline formulations for patients with ethylenediamine sensitivity.