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Updated: Jun 28, 2026
10:42
Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
A solid-phase spectrophotometric method for the determination of sulphathiazole
L F Capitán-Vallvey1, I de Orbe, M C Valencia
1Department of Analytical Chemistry. University of Granada, Granada, Spain.
Talanta
|August 1, 1994
Summary
A new solid-phase spectrophotometric method accurately determines sulphathiazole (ST) in pharmaceuticals. This validated technique offers a low detection limit and high precision for ST analysis.
Area of Science:
- Analytical Chemistry
- Spectroscopy
- Pharmaceutical Analysis
Background:
- Accurate quantification of sulphathiazole (ST) is crucial for pharmaceutical quality control.
- Existing analytical methods may require improvement in sensitivity or efficiency.
Purpose of the Study:
- To develop and validate a novel spectrophotometric method for sulphathiazole determination.
- To evaluate the method's performance using solid-phase spectrophotometry.
Main Methods:
- Solid-phase spectrophotometry utilizing Sephadex SP C-25 for analyte fixation.
- Investigation of experimental variables influencing Sephadex SP C-25 fixation.
- Validation of the method for accuracy, precision, and detection limit.
Main Results:
- The developed method demonstrated an applicable concentration range of 0.10-10.00 mg/l.
- A low detection limit of 0.02 mg/l and a relative standard deviation of 0.62% were achieved.
- The method showed satisfactory accuracy and precision.
Conclusions:
- A reliable and sensitive solid-phase spectrophotometric method for sulphathiazole determination has been established.
- The method is suitable for the quantitative analysis of sulphathiazole in pharmaceutical formulations.
- This technique offers a valuable tool for pharmaceutical quality control and drug analysis.
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