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Updated: Jun 28, 2026

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
Published on: February 8, 2017
Transport of Cu(II) with hydroxamic acid through a liquid membrane
1Department of Applied Chemistry, Faculty of Engineering, Kanagawa University, Kanagawa-ku, Yokohama, 221, Japan.
Abstract:
N-Hydroxy-N-naphthylbenzamides (3) were synthesized for examining their ability to extract and transport Cu(II) through a liquid membrane. The transport was proton-driven and was capable of moving metal ions ;up-hill'. Thus, it was possible to follow the transfer of Cu(II) from the aqueous source phase to the organic layer and from the organic layer to the receiving phase. The N-hydroxy-N-(2-naphthyl)benzamide (3b) carrier displayed much more remarkable selectivity for Cu(II) compared with N-hydroxy-N-(1-naphthyl)benzamide (3a). This difference in selectivity was explained in terms of the stability of the Cu(II) complex in chloroform.
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