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An optimization procedure for determination of indomethacin and acemethacin by differential pulse adsorptive
C Reguera1, M Julia Arcos, M Cruz Ortiz
1Departamento de Quimica (Area de Quimica Analitica), Facultad de Ciencias, Universidad de Burgos, Pza. Misael Bañuelos, 09001 Burgos, Spain.
Abstract:
Procedures for the determination of indomethacin and acemethacin by differential pulse adsorptive stripping voltammetry with a mercury electrode have been described and optimised. The selection and optimization of the experimental parameters was done using factorial and central composite designs. Indomethacin and acemethacin in urine were determined by this method with good results and without the need for tedious prior separation. For routine calibration and calculation of the 'capacity to detect', the robust regression method least median squares (LMS) has been proposed.
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