Integrated flow injection-solid phase spectrophotometric determination of minoxidil

Area of Science:

• Analytical Chemistry
• Spectroscopy
• Chemical Sensing

Background:

• Minoxidil determination is crucial for pharmaceutical quality control.
• Existing methods may require complex procedures or derivatization.
• Development of rapid and sensitive analytical techniques is ongoing.

Purpose of the Study:

• To develop a flow-through solid phase spectrophotometric (SPS) sensing device for minoxidil determination.
• To establish a sensitive and efficient method for analyzing minoxidil in pharmaceutical samples.
• To compare the developed method with established techniques like HPLC.

Main Methods:

• Utilized a flow-through system with Sephadex SP-C25 ion-exchanger in a flow cell.
• Employed UV-Vis spectrophotometry at 282 nm for direct monitoring without derivatization.
• Optimized carrier/desorbing solution (HCl/NaCl) and sample volumes.

Main Results:

• Achieved linear responses for minoxidil in the ranges of 0.2-7, 0.1-4, and 0.05-2 µg/mL.
• Obtained detection limits as low as 6 ng/mL with varying sample volumes.
• Demonstrated satisfactory performance in determining minoxidil in pharmaceutical preparations.

Conclusions:

• The proposed SPS sensing device provides a sensitive and effective method for minoxidil quantification.
• The technique is suitable for routine analysis of minoxidil in pharmaceutical formulations.
• The SPS method shows potential as a viable alternative to HPLC for minoxidil analysis.