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08:41
Electrochemical Impedance Spectroscopy as a Tool for Electrochemical Rate Constant Estimation
Published on: October 10, 2018
Differential electrolytic potentiometry, a detector in flow injection analysis for oxidation-reduction reactions
A M Abulkibash1, M E Koken, M M Khaled
1Chemistry Department, King Fahd University, P.O. Box 2026, Dhahran 31261, Saudi Arabia.
Talanta
|October 31, 2008
Summary
A new method combines differential electropotentiometry (DEP) with flow injection analysis (FIA) for vitamin C determination. This technique accurately quantifies vitamin C in pharmaceuticals without interference from excipients.
Area of Science:
- Analytical Chemistry
- Electrochemistry
Background:
- Quantitative determination of vitamin C is crucial in pharmaceutical analysis.
- Existing methods may face interference from pharmaceutical excipients.
Purpose of the Study:
- To develop and validate a novel analytical method for vitamin C quantification.
- To couple differential electropotentiometry (DEP) with flow injection analysis (FIA) for enhanced detection.
Main Methods:
- Utilized differential electropotentiometry (DEP) coupled with flow injection analysis (FIA).
- Employed two platinum electrodes polarized by a constant current.
- Optimized parameters including current density, flow rate, sample size, and sulfuric acid concentration.
Main Results:
- Successfully quantified vitamin C in the range of 100-300 ppm with a high correlation coefficient (0.9987).
- Achieved a low standard deviation (1.9), indicating method precision.
- Demonstrated no interference from common pharmaceutical excipients.
Conclusions:
- The developed DEP-FIA method is suitable for the accurate determination of vitamin C in pharmaceutical preparations.
- The method offers a reliable alternative to standard analytical techniques for vitamin C analysis.
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