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Case report 679. Central low-grade osteosarcoma with foci of dedifferentiation
Y Iemoto1, S Ushigome, M Fukunaga
1Department of Pathology, Jikei University, School of Medicine, Tokyo, Japan.
Skeletal Radiology
|January 1, 1991
Abstract:
An infrequently encountered case of well-differentiated CLOS containing dedifferentiated tumor foci in a 28-year-old Japanese man is reported. The patient died from widespread metastases with a microscopic appearance identical to the anaplastic dedifferentiated lesions of the original tumor. This is, to our knowledge, the first report of a case of CLOS with dedifferentiation at the time of initial surgery. The literature concerning CLOS was reviewed and the diagnostic features of CLOS discussed.