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Updated: Jun 28, 2026

Multi-analyte Biochip (MAB) Based on All-solid-state Ion-selective Electrodes (ASSISE) for Physiological Research
Published on: April 18, 2013
New lead (II) selective membrane potentiometric sensors based on chiral 2,6-bis-pyridinecarboximide derivatives
Saad S M Hassan1, M H Abou Ghalia, Abdel-Galil E Amr
1Department of Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt.
Abstract:
New membrane sensors with cylindrical configuration for lead (II) ions are described based on the use of three newly synthesized pyridine carboximide derivatives as neutral ionophores in plasticized PVC membranes. The sensors exhibit significantly enhanced response towards lead (II) ions over the concentration range 4x10(-6)-1x10(-2) mol l(-1) at pH 4.5-7 with a lower detection limit of 0.4-3.7 mug ml(-1). The sensors display near-Nernstian slope of 26.0-33.1 mV per decade for Pb(II) ions. Effects of plasticizers, lipophilic salts and various foreign common ions are tested. The sensors show long life span, good selectivity for Pb(II) over a wide variety of other metal ions, long term stability, high reproducibility, and fast response. Validation of the method by measuring the lower detection limit, range, accuracy, precision, repeatability and between-day-variability reveals good performance characteristics of the proposed sensors. The sensors are used for direct determination of lead in stack emissions of lead smelters, assay of lead in rocks and monitoring of potentiometric titration of Pb(II) with EDTA. The results obtained agree fairly well with data obtained by atomic absorption spectrometry.
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