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Related Concept Videos

Controlled-Current Coulometry: Coulometric Titration01:18

Controlled-Current Coulometry: Coulometric Titration

Coulometric titrations are a form of titrimetric analysis where the reagent is generated electrically, and its amount is evaluated based on current and generating time. The electron serves as the standard reagent. The procedure is similar to conventional titrations, such as endpoint detection.
The fundamental requirements for coulometric titrations are (1) 100% efficiency in the reagent-generating electrode reaction and (2) a stoichiometric and preferably rapid reaction between the generated...
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Controlled current coulometry, also known as amperostatic coulometry, is a technique used in electrochemical analysis to measure the quantity of a substance through the controlled passage of current. It involves the application of a constant current to an electrochemical cell containing the analyte of interest. As the current flows through the cell, the analyte undergoes a redox reaction at the electrode surface, resulting in a charge transfer. By monitoring the time required for a certain...
Titrimetric Methods: Types and Commonly Used Strategies01:08

Titrimetric Methods: Types and Commonly Used Strategies

In chemistry, titrimetric methods are broadly classified into three types: volumetric, gravimetric, and coulometric. Volumetric titrations involve measuring the volume of a titrant of known concentration that is required to react completely with an analyte. In gravimetric titrations, the standard solution reacts with the analyte to form an insoluble precipitate, which is filtered, dried, and weighed. In coulometric titrations, current is applied to an electrochemical reaction until the reaction...
Fast Reactions01:27

Fast Reactions

Fast reactions occurring in times shorter than the time needed to mix reactants pose a unique challenge for investigation. In a liquid-phase continuous-flow system, reactants A and B are swiftly pushed into the mixing chamber, where mixing occurs within 1 ms. The reaction mixture then flows through an observation tube, and one measures light absorption to determine species concentrations at various points of the tube. This method is most appropriate when relatively large volumes of reactants...
Classification of Titrimetric Analysis Based on Reaction Types01:01

Classification of Titrimetric Analysis Based on Reaction Types

Titrimetric analysis in solution chemistry involves measuring the volume of solutions and is often called volumetric analysis. The standard solution of known concentration in the burette is called the titrant, whereas the solution of unknown concentration in the flask is called the analyte, or titrand. Titrimetric analyses can be classified into four types based on the reactions between the titrant and analyte.
Titrations between an acid and a base lead to neutralization reactions that form...
Potentiometric Titration: Overview01:31

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Potentiometric titration is a quantitative analytical technique that determines the concentration of an analyte by measuring the potential difference between the two electrodes in the solution. The endpoint of a potentiometric titration is the point at which there is a significant change in the potential difference. It occurs when the stoichiometric reaction between the analyte and the titrant is complete. The endpoint is usually determined graphically by plotting the measured potential...

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High throughput continuous titration based on a flow ratiometry controlled with feedback-based variable triangular

Hideji Tanaka1, Tsutomu Baba

  • 1Institute of Health Biosciences, Tokushima University, Shomachi 1-78-1, Tokushima, Japan. htanaka@ph.tokushima-u.ac.jp

Talanta
|October 31, 2008
PubMed
Summary
This summary is machine-generated.

This study introduces a high-throughput continuous titration method using flow ratiometry. The novel approach achieves rapid analysis by precisely controlling flow rates, enabling up to 17.6 titrations per minute.

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Area of Science:

  • Analytical Chemistry
  • Chemical Engineering

Background:

  • Traditional titration methods can be time-consuming.
  • High-throughput analysis is crucial for many chemical processes.

Purpose of the Study:

  • To develop a high-throughput continuous titration method.
  • To apply flow ratiometry for automated potentiometric titrations.

Main Methods:

  • Utilized flow ratiometry with variable base flow rate controlled by voltage.
  • Implemented a feedback system to detect the equivalence point (EP).
  • Employed fixed triangular voltage waves for rapid, automated titrations.

Main Results:

  • Achieved a maximum throughput of 17.6 titrations per minute (3.4 seconds per titration).
  • Demonstrated high precision with a relative standard deviation (R.S.D.) of 0.35%.
  • Successfully applied the method to potentiometric titrations of acids and bases.

Conclusions:

  • The proposed flow ratiometry method significantly enhances titration throughput.
  • Automated control around the equivalence point is key to rapid analysis.
  • This technique offers a valuable tool for high-speed chemical analysis.