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Related Experiment Video

Updated: Jun 28, 2026

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

Published on: November 23, 2015

A palm-sized surface plasmon resonance sensor with microchip flow cell.

Hizuru Nakajima¹, Yuuki Harada, Yasukazu Asano

¹Faculty of Urban Environmental Sciences, Tokyo Metropolitan University, 1-1 Minamiohsawa, Hachioji, Tokyo 192-0364, Japan.

|October 31, 2008

Summary

A novel microchip surface plasmon resonance (SPR) sensor significantly enhances detection sensitivity for low molecular weight compounds. This portable SPR detector shows dramatically improved performance for substances like sucrose and IgA.

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Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

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Area of Science:

Analytical Chemistry
Biosensing Technology

Background:

Surface Plasmon Resonance (SPR) is a powerful technique for detecting molecular interactions.
Enhancing SPR sensitivity for low molecular weight compounds remains a challenge.

Purpose of the Study:

To develop a small-sized SPR sensor with a microchip flow cell to improve sensitivity for low molecular weight compounds.
To investigate the effect of microchip dimensions on SPR intensity and sensitivity.

Main Methods:

Fabrication of a portable differential SPR detector using a polydimethylsiloxane/gold microchip with dual flow paths.
Utilized a microchip flow cell with dimensions of 10mm (L)x1mm (W)x20-100µm (D).
Performance evaluation using sucrose and immunoglobulin A (IgA) as analytes.

Main Results:

The microchip SPR sensor demonstrated a drastic increase in SPR intensity.
Flow cell depth was found to be inversely proportional to SPR intensity.
Sensitivity increased approximately 11-fold for 10% sucrose and 39-fold for 0.9nM IgA compared to conventional flow cells.

Conclusions:

The microchip SPR sensor design significantly enhances detection capabilities for low molecular weight substances.
The observed size effect in the microchip contributes to the improved SPR intensity.
This technology holds promise for advancing SPR-based measurements, particularly for small molecules.