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Related Concept Videos

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...

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Orthotopic Injection of Breast Cancer Cells into the Mammary Fat Pad of Mice to Study Tumor Growth.
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Cancer as an endocrine problem.

Jeff M P Holly1, Claire M Perks

  • 1Department of Clinical Science at North Bristol, University of Bristol, Paul O'Gorman Lifeline Centre, Southmead Hospital, Bristol BS10 5NB, UK. jeff.holly@bristol.ac.uk

Best Practice & Research. Clinical Endocrinology & Metabolism
|October 31, 2008
PubMed
Summary

Environmental factors, particularly nutrition, significantly influence cancer development. Lifestyle interventions targeting nutrition, metabolism, and hormones show promise for cancer prevention.

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Orthotopic Injection of Breast Cancer Cells into the Mammary Fat Pad of Mice to Study Tumor Growth.
07:52

Orthotopic Injection of Breast Cancer Cells into the Mammary Fat Pad of Mice to Study Tumor Growth.

Published on: February 8, 2015

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
09:48

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells

Published on: September 12, 2019

Area of Science:

  • Oncology
  • Environmental Health
  • Endocrinology

Background:

  • Geographical variations in common cancer incidence suggest environmental, not genetic, causes.
  • Westernized societies exhibit widespread metabolic and hormonal disturbances linked to nutrition.
  • Cancer development is increasingly understood to involve cell signaling pathways central to metabolism.

Purpose of the Study:

  • To explore the role of environmental factors, specifically nutrition, in cancer development.
  • To investigate the link between metabolic status, hormonal perturbations, and cancer progression.
  • To highlight the potential for preventative strategies based on nutritional and endocrine interventions.

Main Methods:

  • Review of epidemiological data on cancer incidence in migrant populations.
  • Analysis of clinical indicators of metabolic and hormonal status in Westernized societies.
  • Examination of genomic data from breast and colorectal cancers to identify critical cell signaling pathways.

Main Results:

  • Environmental exposures, especially nutrition, are key determinants of cancer incidence.
  • Metabolic and hormonal imbalances are prevalent and likely mediate cancer development.
  • Critical cell signaling pathways in cancer are also central to cell metabolism and hormonal control.

Conclusions:

  • Many common cancers may be preventable through lifestyle interventions.
  • Nutrition, metabolic status, and endocrine control are crucial factors in cancer prevention.
  • Targeting these factors offers promising strategies for reducing cancer burden.