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Related Experiment Video

Updated: Jun 28, 2026

Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice

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Published on: December 8, 2023

Solid cancers after allogeneic hematopoietic cell transplantation.

J Douglas Rizzo¹, Rochelle E Curtis, Gérard Socié

¹Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI 53226, USA. izzo@mcw.edu

|October 31, 2008

Summary

This summary is machine-generated.

Allogeneic transplant survivors face double the general population risk of solid cancers, with risk increasing over time. Young patients receiving radiation have a significantly higher risk of non-squamous cell carcinoma.

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Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

Published on: August 31, 2016

Area of Science:

Oncology
Hematology
Transplantation Medicine

Background:

Allogeneic transplant recipients have an increased risk of solid cancers.
Previous studies were limited in evaluating host, disease, and treatment factors.
This is the largest study to date on solid cancer risk in this population.

Purpose of the Study:

To evaluate risk factors for solid cancers in a large cohort of allogeneic transplant recipients.
To investigate the interaction of host, disease, and treatment-related factors.
To identify specific risk factors for different cancer types (SCC vs. non-SCC).

Main Methods:

Multi-institutional cohort study.
Analysis of 28,874 allogeneic transplant recipients.
Inclusion of 189 solid malignancies for analysis.

Main Results:

Overall solid cancer incidence was twice the general population rate (O:E = 2.1).
Cancer risk increased with time post-transplant, reaching 3-fold at 15+ years.
Non-SCC risk was 9x higher in patients irradiated <30 years old, dependent on age at exposure.
Chronic graft-versus-host disease and male sex were key determinants for SCC risk.

Conclusions:

Allogeneic transplant survivors have a significantly increased risk of developing solid cancers.
Lifelong surveillance is recommended, especially for those irradiated at young ages.
Age at radiation exposure is a critical factor for non-SCC development.