Related Experiment Video
Updated: Jun 28, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
Studies on development of insoluble drugs as pharmaceutical suspensions by response surface methodology
1Department of Pharmaceutics, Faculty of Pharmacy, Health Science Center, Kuwait University, Kuwait. Khattab@hsc.edu.kw
Abstract:
The preformulation of insoluble drugs, trimethoprim and nitrofurantoin, was studied in order to achieve a suspension with desirable requirements. The objective of the formulator is to avoid the irreversible aggregation called "caking", and to obtain a suspension with an airy, large volume sediment easily redispersible and with suitable rheological properties. An experimental design useful to determine optimal properties is a Box-Behnken design. The surfactant, thickener and electrolyte at different proportions were the three factors studied. This strategy allows to point on the main significant effect and to determine the concentrations of each product leading to optimal properties of the suspensions.
More Related Videos
Related Concept Videos
Factors Affecting Dissolution: Particle Size and Effective Surface Area
In Vitro Drug Dissolution: Compendial Testing Models I
In Vitro Drug Dissolution: Alternative Methods
Factors Influencing Drug Absorption: Pharmaceutical Parameters
In Vitro Drug Dissolution: Compendial Testing Models II
Drug Dissolution: Requirements and Profile Comparison

