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Preoperative chemoradiation for locally advanced rectal cancer with capecitabine 2,000 mg/m2/day
Vutisiri Veerasarn1, Wiroon Boonnuch, Vitoon Chinswangwatanakul
1Division of Radiation Oncology, Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. vutisiri@hotmail.com
Objective:
Evaluate the efficacy and the tolerability of preoperative chemoradiation with high dose Capecitabine.
Material And Method:
Fifteen patients with locally advanced resectable rectal cancer were treated with Capecitabine 2,000 mg/m2/day, orally 7 days/week concurrent with whole pelvic irradiation 45 Gy in 25 fractions/5 weeks. Patients underwent surgery in the following 4-6 weeks.
Results:
After complete treatment, 11 patients (73%) underwent surgery. Ten patients (66%) had sphincter preservative surgery; three of them had primary tumors located in the lower rectum. Five patients had grade 2 and one patient had grade 3 diarrhea. No grade 4 toxicity was reported.
Conclusion:
Preoperative Capecitabine 2,000 mg/m2/day concurrent with whole pelvic irradiation were effective and well tolerated The potential dose limiting toxicity effect was the diarrhea.
