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[Comparative research on anticancer activity between fresh and processed Gekko subpalmatus].

Xin-Nan Hou¹, Di Geng, Ang Cai

¹Department of Biological Pharmaceutics, School of Chinese Pharmacy, Beijing University of Traditional Chinese Medicine, Beijing 100102, China.

Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials

|November 1, 2008

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Fresh and processed Gekko subpalmatus demonstrated significant anticancer effects against mouse H22 hepatocellular carcinoma. Processed samples also showed potential to enhance immune function in mice.

Area of Science:

Pharmacology
Immunology
Oncology

Background:

Hepatocellular carcinoma (HCC) remains a significant global health challenge.
Exploring novel therapeutic agents for HCC is crucial.
Gekko subpalmatus is traditionally used, but its scientific validation for anticancer activity is limited.

Purpose of the Study:

To comparatively evaluate the in vitro and in vivo anticancer efficacy of fresh and processed Gekko subpalmatus against mouse H22 hepatocellular carcinoma.
To assess the impact of Gekko subpalmatus on immune parameters.

Main Methods:

In vitro cytotoxicity was assessed using the Monotetrazolium (MTT) assay.
An in vivo mouse model of transplanted hepatoma H22 was established.
Tumor growth inhibition rates and thymus/spleen indices were measured after 14 days of treatment.

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Main Results:

Both fresh and processed Gekko subpalmatus inhibited H22 cell proliferation in vitro, with IC50 values of 8.53 mg/ml and 6.42 mg/ml, respectively.
In vivo, highest doses achieved tumor restraining rates of 53.0% (fresh) and 47.4% (processed).
Processed Gekko subpalmatus treatment significantly increased thymus and spleen indices compared to the CTX group, suggesting immunomodulatory effects.

Conclusions:

Gekko subpalmatus, in both fresh and processed forms, exhibits significant anti-tumor activity against hepatocellular carcinoma cells.
Processed Gekko subpalmatus demonstrates potential in improving host immunity, offering a dual therapeutic approach.