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Updated: Jun 28, 2026
Fertility Preservation in Patients with Severe Ovarian Dysfunction
Published on: March 25, 2021
Low-dose aspirin in non-tubal IVF patients with previous failed conception: a prospective randomized double-blind
Marieke J Lambers1, Diederik A Hoozemans1, Roel Schats1
1Department of Obstetrics, Gynecology and Reproductive Medicine Free University Medical Center, Amsterdam, The Netherlands.
Objective:
To analyze whether the administration of low-dose aspirin during IVF treatment improves the uterine blood flow and improves ongoing pregnancy rates for non-tubal factor IVF patients with previous failed conception.
Design:
Prospective double-blind placebo-controlled trial.
Setting:
University fertility clinic.
Patient(S):
Non-tubal IVF patients with previous failed conception.
Intervention(S):
Daily 100 mg aspirin or placebo throughout an IVF treatment with a long GnRH-agonist stimulation protocol.
Main Outcome Measure(S):
Ongoing pregnancy rate, pulsatility index of the uterine artery.
Result(S):
Of 169 patients, 84 were assigned to aspirin treatment and 85 to placebo treatment. In the aspirin group, 28 patients (35.4%) had an ongoing pregnancy, and in the placebo group, 26 patients (31.0%) had an ongoing pregnancy. Multilevel analyses showed that the pulsatility index of the uterine artery was not affected by aspirin or placebo treatment.
Conclusion(S):
Low-dose aspirin administration during IVF treatment does not improve pregnancy rates of non-tubal factor IVF patients with previous failed conception, and it does not affect the arterial uterine blood flow.
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