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Micro-CT Imaging and Morphometric Analysis of Mouse Neonatal Brains
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The Neuroterrain 3D Mouse Brain Atlas.
Louise Bertrand1, Jonathan Nissanov
1Department of Neurobiology and Anatomy, Drexel University College of Medicine Philadelphia, PA, USA.
Frontiers in Neuroinformatics
|November 1, 2008
Summary
Researchers developed a new anatomical atlas for the C57BL/6J mouse brain. This neuroinformatics tool aids in the automated analysis of histological images for neurogenetic research.
Area of Science:
- Neuroinformatics
- Neuroimaging
- Computational Neuroscience
Background:
- Neuroinformatics aims to create tools for accessing, searching, and analyzing anatomical imagery.
- Image analysis tools include registration algorithms and anatomical models (atlases).
Purpose of the Study:
- To construct an anatomical atlas model for the C57BL/6J mouse.
- To support automated delineation of the Mouse Brain Library database.
Main Methods:
- Development of computer vision tools for mesoscale image analysis.
- Creation of an atlas containing bitmap images and anatomical boundary templates.
Main Results:
- Construction of a novel anatomical atlas for the C57BL/6J mouse.
- The atlas serves as a model for automated image analysis.
Conclusions:
- The developed mouse brain atlas is a valuable tool for neuroinformatics.
- It facilitates automated delineation for neurogenetic research databases.
