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Updated: Jun 28, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis and antitumor activity of 3-arylisoquinoline derivatives
1College of Pharmacy, Chonnam National University, Yongbong-dong 300 Buk-gu, 500-757, Kwangju, Korea.
Abstract:
In order to study the structure-activity relationship of 7,8-dimethoxy-2-methyl-3-(4,5-methylen-edioxy-2-vinylphenyl)isoquinoline-1 (2H)-one (2), which has exhibited significant antitumor activity, chemical modifications of2 were performed to yield the corresponding products (3-7). Further systematic uses of an efficient procedure for the synthesis of 3-arylisoquinoline derivatives produced the substituted compounds (9a-9g), which were tested forin vitro antitumor activity against five different human cancer cell lines.
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