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Related Concept Videos

Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
Antiviral Nucleoside Inhibitors01:22

Antiviral Nucleoside Inhibitors

Antiviral Nucleoside InhibitorsAntiviral nucleoside inhibitors are structural analogs of natural nucleosides that interfere with viral DNA or RNA synthesis. These compounds selectively target viral polymerases due to their resemblance to host nucleosides, thereby disrupting viral genome replication.Mechanism of Acyclovir ActionAcyclovir is a guanosine analog with a three-carbon acyclic side chain. It selectively targets herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2),...
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.

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Updated: Jun 28, 2026

Subconjunctival Administration of Adeno-associated Virus Vectors in Small Animal Models
06:16

Subconjunctival Administration of Adeno-associated Virus Vectors in Small Animal Models

Published on: March 16, 2022

Acyclovir delivery systems.

Rita Cortesi1, Elisabetta Esposito

  • 1University of Ferrara, Department of Pharmaceutical Sciences, CoReS Techno Group, Via Fossato di Mortara, 19-44100 Ferrara, Italy. crt@unife.it

Expert Opinion on Drug Delivery
|November 4, 2008
PubMed
Summary
This summary is machine-generated.

New delivery systems for acyclovir offer a promising alternative for treating herpes virus infections. This review highlights advances in acyclovir carriers for various administration routes.

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Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting
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Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting

Published on: October 26, 2018

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Last Updated: Jun 28, 2026

Subconjunctival Administration of Adeno-associated Virus Vectors in Small Animal Models
06:16

Subconjunctival Administration of Adeno-associated Virus Vectors in Small Animal Models

Published on: March 16, 2022

Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting
08:14

Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting

Published on: October 26, 2018

Area of Science:

  • Virology
  • Pharmacology
  • Drug Delivery Systems

Background:

  • Herpes viruses, including herpes simplex, varicella zoster, and cytomegalovirus, are significant causes of human infections.
  • Antiviral treatment development for herpes viruses has historically been slow.
  • Acyclovir is a key antiviral agent, but its efficacy can be improved through advanced delivery methods.

Purpose of the Study:

  • To review recent advancements in acyclovir delivery systems.
  • To explore various routes of administration for acyclovir carriers.
  • To provide an overview of promising alternatives for herpes virus infection treatment.

Main Methods:

  • Literature review of scientific publications.
  • Analysis of studies on acyclovir carrier development.
  • Synthesis of information on different administration routes for acyclovir delivery systems.

Main Results:

  • Significant progress has been made in developing novel carriers for acyclovir.
  • Various administration routes are being explored to enhance acyclovir bioavailability and efficacy.
  • Emerging delivery systems show potential for improved treatment outcomes.

Conclusions:

  • Advanced acyclovir delivery systems represent a promising strategy against herpes virus infections.
  • Continued research into drug carriers can overcome limitations of traditional antiviral therapies.
  • Optimized acyclovir delivery holds potential for more effective management of herpes viral diseases.