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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
07:59

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

Terpenoids from Dysoxylum densiflorum.

Bo-Jun Xie1, Sheng-Ping Yang, Jian-Min Yue

  • 1State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Zhangjiang Hi-Tech Park, Shanghai, People's Republic of China.

Phytochemistry
|November 4, 2008
PubMed
Summary
This summary is machine-generated.

Researchers isolated six new dysodensiols, three limonoids and three sesquiterpenoids, from Dysoxylum densiflorum. Their structures were determined using spectroscopic analysis, contributing to natural product chemistry.

Related Experiment Videos

Last Updated: Jun 28, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
07:59

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

Area of Science:

  • Natural Product Chemistry
  • Organic Chemistry
  • Phytochemistry

Background:

  • Dysoxylum densiflorum is a plant species known to produce bioactive compounds.
  • Limonoids and sesquiterpenoids are classes of natural products with diverse chemical structures and biological activities.

Purpose of the Study:

  • To isolate and characterize new chemical constituents from Dysoxylum densiflorum.
  • To elucidate the structures of novel limonoid and sesquiterpenoid compounds.

Main Methods:

  • Phytochemical investigation of plant extracts using chromatographic separation techniques.
  • Structure elucidation of isolated compounds employing extensive spectroscopic analyses (e.g., NMR, MS).

Main Results:

  • Isolation of three new degraded limonoids, named dysodensiols A-C (compounds 1-3).
  • Isolation of three new sesquiterpenoids, named dysodensiols D-F (compounds 4-6).
  • Identification of 17 known compounds alongside the six new natural products.

Conclusions:

  • The study successfully identified novel limonoid and sesquiterpenoid compounds from Dysoxylum densiflorum.
  • The structural characterization provides valuable data for understanding the chemical diversity of this plant species.