Related Experiment Video
Updated: Jun 28, 2026

A Freeze-Thawing Method to Prepare Chitosan-Poly(vinyl alcohol) Hydrogels Without Crosslinking Agents and Diflunisal Release Studies
Published on: January 14, 2020
Synthesis of dehydroabietic acid-modified chitosan and its drug release behavior
Wengui Duan1, Changmao Shen, Huaxiang Fang
1School of Chemistry and Chemical Engineering, Guangxi University, No. 100, Daxue Road, Nanning, Guangxi 530004, People's Republic of China. wgduan@gxu.edu.cn
Abstract:
A new type of chitosan derivative, dehydroabietic acid-modified chitosan (DAMC), was synthesized by the acylation reaction of chitosan with dehydroabietic acid chloride (DHAC) under microwave irradiation. The resulting product (DAMC) was characterized by FT-IR, UV, (1)H NMR, X-ray diffraction (XRD), scanning electron microscopy (SEM), thermal gravimetric analysis (TGA), and elemental analysis. The degree of substitution (DS) of DAMC was 16.5%. And chitosan and DAMC were used as carriers of fenoprofen calcium (FC), and their controlled release behavior in artificial intestinal juice was studied. The results showed that the controlled release of FC from the carrier of DAMC is better than that from original chitosan.
Related Concept Videos
Modified-Release Drug Delivery Systems: Drug Release Characteristics
Modified-Release Drug Delivery Systems: Influencing Factors
Modified-Release Drug Delivery Systems: Bioavailability
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Modified-Release Drug Delivery Systems: Rate-Programmed I
Bioavailability Enhancement: Drug Solubility Enhancement

