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Related Concept Videos

Inflammation01:38

Inflammation

Overview
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Acute Inflammation II: Cellular Phase01:26

Acute Inflammation II: Cellular Phase

The cellular phase of acute inflammation is a tightly orchestrated sequence of events that recruits leukocytes, primarily neutrophils, to sites of tissue injury or infection. Following the initial vascular changes, this phase ensures effective immune cell migration, activation, and function at the affected site to eliminate pathogens and initiate tissue repair.Leukocyte Recruitment CascadeLeukocyte recruitment happens in four steps: margination, adhesion, transmigration, and chemotaxis. Reduced...
Inflammation: Introduction01:28

Inflammation: Introduction

Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
Ecological Niches02:02

Ecological Niches

All organisms have a position within an ecosystem. The complete set of living and nonliving factors—including food resources, climate, and terrain—that define the position of a given organism are collectively referred to as the organism’s ecological niche.Multiple species cannot occupy the exact same niche within their habitat. If the niches of two or more species overlap to a large extent, the competitive exclusion principle dictates that one species will outcompete the other, forcing it to...

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Related Experiment Video

Updated: Jun 28, 2026

Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways
06:43

Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways

Published on: January 13, 2016

Inflammation joins the "niche".

Héctor Peinado1, Shahin Rafii, David Lyden

  • 1Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, NY 10021, USA.

Cancer Cell
|November 4, 2008
PubMed
Summary
This summary is machine-generated.

This study reveals how inflammation attracts myeloid and tumor cells to distant sites, aiding cancer metastasis. Understanding this pathway is key to developing new cancer therapies.

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Last Updated: Jun 28, 2026

Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways
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A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

Area of Science:

  • Oncology
  • Cell Biology
  • Immunology

Background:

  • Bone marrow-derived cells are implicated in tumor metastasis.
  • The mechanisms of their recruitment to distant sites remain unclear.
  • These cells are known to "prime" tissues for tumor engraftment.

Discussion:

  • Hiratsuka et al. identify a novel inflammatory signaling pathway.
  • This pathway mediates the chemoattraction of myeloid cells.
  • It also facilitates the recruitment of tumor cells to specific metastatic locations.

Key Insights:

  • A specific inflammatory pathway drives the recruitment of bone marrow-derived myeloid cells.
  • This pathway is crucial for attracting tumor cells to organ-specific metastatic sites.
  • The findings elucidate a critical mechanism in cancer metastasis.

Outlook:

  • Targeting this inflammatory pathway could offer new therapeutic strategies for cancer metastasis.
  • Further research may explore the precise molecular players within this pathway.
  • Understanding cell recruitment mechanisms is vital for improving cancer treatment outcomes.