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Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Asepsis01:28

Asepsis

The condition of being free from disease-causing living pathogens is asepsis. Aseptic techniques include a set of standard practices to achieve asepsis. An example is the regular environmental cleaning of all parts of the healthcare facility and hand hygiene at home before preparing or eating food. Medical and surgical asepsis in healthcare practice protects patients from harmful pathogens, minimizes the risk of contamination of susceptible sites, and reduces the risk of infection transmission.
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...

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Related Experiment Video

Updated: Jun 28, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Methicillin-resistant Staphylococcus aureus in orthopaedic surgery.

A Patel1, R P Calfee, M Plante

  • 1Department of Orthopaedic Surgery, Brown University, Providence, Rhode Island 02903, USA. patel_amar@msn.com

The Journal of Bone and Joint Surgery. British Volume
|November 4, 2008
PubMed
Summary

Methicillin-resistant Staphylococcus aureus (MRSA) is a growing threat in hospitals and communities, affecting athletes and increasing healthcare costs. Understanding MRSA

Related Experiment Videos

Last Updated: Jun 28, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Area of Science:

  • Infectious Diseases
  • Orthopaedic Surgery
  • Bacteriology

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) is prevalent in healthcare and community settings.
  • MRSA infections are increasing in healthy adults, including athletes.
  • Healthcare-associated MRSA significantly impacts patient outcomes and hospital costs.

Purpose of the Study:

  • To review the evolution and pathogenicity of MRSA.
  • To analyze the spectrum of diseases caused by MRSA.
  • To present current prevention and treatment strategies for MRSA orthopaedic infections.

Main Methods:

  • Literature review of MRSA evolution and clinical manifestations.
  • Analysis of disease spectrum and pathogenicity.
  • Synthesis of current prevention and treatment guidelines for orthopaedic infections.

Main Results:

  • MRSA presents distinct challenges in community-acquired and healthcare-associated infections.
  • Athletes are increasingly affected by MRSA outbreaks.
  • Effective prevention and treatment strategies are crucial for managing MRSA orthopaedic infections.

Conclusions:

  • The orthopaedic community requires fundamental knowledge of MRSA.
  • Understanding MRSA's evolution and disease spectrum is vital.
  • Current strategies focus on prevention and tailored treatment for MRSA orthopaedic infections.