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Updated: Jun 28, 2026

Quantifying the Antifungal Activity of Peptides Against Candida albicans

Quantifying the Antifungal Activity of Peptides Against Candida albicans

Published on: January 13, 2023

Antifungals in the ICU.

Elliott Geoffrey Playford¹, Philippe Eggimann, Thierry Calandra

¹Infection Management Services, Princess Alexandra Hospital, Brisbane, Australia. geoffrey_playford@health.qld.gov.au

Current Opinion in Infectious Diseases

|November 4, 2008

Summary

Echinocandins show high efficacy for treating invasive candidiasis in ICU patients, potentially replacing fluconazole. Early, targeted antifungal therapies improve outcomes.

Area of Science:

Critical Care Medicine
Infectious Diseases
Pharmacology

Background:

Invasive fungal infections, particularly candidiasis, pose a significant threat to critically ill patients in intensive care units (ICUs).
Optimizing antifungal therapy is crucial for improving patient outcomes in this vulnerable population.

Purpose of the Study:

To review recent efficacy data for newer antifungal agents in treating invasive candidiasis.
To examine the impact of epidemiological shifts, diagnostic advancements, and risk prediction on antifungal therapy optimization.

Main Methods:

Review of recent clinical trials and epidemiological data.
Analysis of diagnostic techniques and clinical prediction models for antifungal intervention.

Main Results:

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Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds

Published on: February 14, 2018

Echinocandins and newer triazoles demonstrate clinical efficacy against invasive candidiasis, with rare resistance to echinocandins.
Epidemiological changes in Candida species may impact fluconazole's first-line use.
Advancements in diagnostics and prediction models aim for earlier, targeted antifungal strategies.

Conclusions:

Echinocandins are poised to become the preferred initial antifungal agents for critically ill ICU patients due to efficacy, spectrum, and pharmacology.
Optimized patient outcomes depend on precisely targeted early antifungal interventions using sensitive and specific risk markers.