Related Experiment Video
Updated: Jun 28, 2026
03:47
A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients
Published on: October 25, 2024
Tuberculous peritonitis after treatment with adalimumab
Jose Antolín1, Marcos Azahara, Clara Hernández
1Internal Medicine, San Carlos Clinic Hospital, Madrid, Spain. pepe.antolin@gmail.com
Scandinavian Journal of Infectious Diseases
|November 4, 2008
Summary
We report a rare case of tuberculous peritonitis in a rheumatoid arthritis patient on adalimumab. This highlights the need to consider tuberculosis in patients receiving anti-tumour necrosis factor therapy.
Area of Science:
- Immunology
- Rheumatology
- Infectious Diseases
Background:
- Rheumatoid arthritis (RA) is a chronic autoimmune disease.
- Anti-tumour necrosis factor (anti-TNF) therapies, including adalimumab, are effective RA treatments.
- Anti-TNF therapy can increase the risk of infections, including tuberculosis.
Observation:
- A case of tuberculous peritonitis occurred in a woman with RA treated with adalimumab.
- This is one of the few reported cases of peritoneal tuberculosis linked to anti-TNF therapy.
- Specifically, it is one of the very few cases associated with adalimumab.
Findings:
- The case demonstrates a potential association between adalimumab use and tuberculous peritonitis.
- A review of existing literature reveals limited reports of peritoneal tuberculosis with anti-TNF agents.
Implications:
- Clinicians should maintain a high index of suspicion for tuberculosis in RA patients on anti-TNF therapy.
- Screening for tuberculosis before initiating anti-TNF therapy is crucial.
- Further research is needed to fully understand the risk and management of tuberculosis during anti-TNF treatment.
Related Concept Videos
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...
01:29Appendicitis-II: Diagnostic Studies and Management
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
01:25Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...