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Preparation of hierarchical hollow CaCO3 particles and the application as anticancer drug carrier
Wei Wei1, Guang-Hui Ma, Gang Hu
1Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, PR China.
Abstract:
One-pot approach to couple the crystallization of CaCO(3) nanoparticles and the in situ symmetry-breaking assembly of these crystallites into hollow spherical shells was developed under the templating effect of a soluble starch. Further functional study using HP-a as an anticancer drug carrier (DOX) demonstrated its advantages for localizing drug release by the pH value-sensitive structure and enhancing cytotoxicity by increasing cellular uptake, perinuclear accumulation, and nuclear entry.

