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Updated: Jun 28, 2026

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Published on: September 13, 2018

VIPERdb2: an enhanced and web API enabled relational database for structural virology.

Mauricio Carrillo-Tripp¹, Craig M Shepherd, Ian A Borelli

¹Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Nucleic Acids Research

|November 5, 2008

Summary

This summary is machine-generated.

VIPERdb(2) is a new release of a virus capsid database, offering novel Phi-Psi diagrams for residue analysis. This resource enhances structural bioinformatics for the virology community.

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Last Updated: Jun 28, 2026

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Published on: September 13, 2018

Area of Science:

Structural biology
Virology
Bioinformatics

Background:

Icosahedral virus capsid structures are crucial for understanding viral assembly and function.
Existing databases may lack specialized tools for detailed analysis of capsid protein residues.

Purpose of the Study:

To enhance VIPERdb as a comprehensive resource for icosahedral virus capsid structures.
To introduce novel methods for analyzing capsid protein residues and their conservation.

Main Methods:

Implementation of azimuthal polar orthographic projections (Phi-Psi diagrams) for residue representation.
Development of an Application Programming Interface (API) for dynamic database interaction.
Integration with visualization tools (Jmol) and sequence-structure alignment tools (STRAP).

Main Results:

Phi-Psi diagrams enable mapping of surface, interface, and core residues.
Identification of conserved residues and hotspots at capsid interfaces.
Enhanced interactivity for visualizing and analyzing virus molecular structures.

Conclusions:

VIPERdb(2) provides advanced tools for structural and computational analysis of virus capsids.
The database facilitates structural bioinformatics analysis through improved data representation and interactivity.