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Updated: Jun 28, 2026

Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness
05:51

Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness

Published on: May 3, 2018

Association of new arterial stiffness parameter, the cardio-ankle vascular index, with left ventricular diastolic

Kosuke Sakane1, Toru Miyoshi, Masayuki Doi

  • 1Department of Medicine and Medical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Journal of Atherosclerosis and Thrombosis
|November 5, 2008
PubMed

Insights

Cardio-ankle vascular index (CAVI), a measure of aortic stiffness, is independently associated with left ventricular (LV) diastolic dysfunction in patients with preserved systolic function. Higher CAVI levels indicate increased risk for LV diastolic dysfunction.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Echocardiography

Background:

  • Pulse wave velocity is a common index for aortic stiffness.
  • Cardio-ankle vascular index (CAVI) measures aortic stiffness independently of blood pressure.
  • Left ventricular (LV) diastolic dysfunction affects heart function.

Purpose of the Study:

  • To analyze the relationship between CAVI and LV diastolic dysfunction.
  • To investigate CAVI as a potential biomarker for diastolic dysfunction.
  • To assess CAVI in patients with preserved systolic function.

Main Methods:

  • 119 patients referred for echocardiography were studied.
  • Patients with reduced systolic function were excluded.
  • CAVI was measured, and patients were categorized by LV diastolic function status.

Main Results:

  • CAVI was significantly higher in patients with reduced LV diastolic function.
  • CAVI was independently associated with diastolic function parameters (peak early diastolic velocity/peak atrial diastolic velocity ratio, left atrial diameter).
  • Highest CAVI quartile showed increased odds for LV diastolic dysfunction.

Conclusions:

  • Increased CAVI is independently associated with LV diastolic dysfunction.
  • CAVI may serve as a valuable indicator of diastolic dysfunction in patients with preserved systolic function.
  • This finding highlights the link between aortic stiffness and diastolic heart abnormalities.
Abstract

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