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Association of the composite IL-1 genotype with peri-implantitis: a systematic review
G Huynh-Ba1, N P Lang, M S Tonetti
1Division of Fixed Prosthodontics, School of Dental Medicine, University of Bern, Bern, Switzerland.
Objective:
Cytokine gene polymorphisms may modulate the host response to the bacterial challenge and influence susceptibility to peri-implantitis.
Objective:
To systematically review the evidence of an association between the interleukin-1 (IL-1) composite genotype, i.e. presence of the allele 2 in the gene clusters IL-1A (-889) and in IL-1B (+3953), and peri-implantitis.
Material And Methods:
An electronic search in the National Library of Medicine-computerized bibliographic database MEDLINE and a manual search were performed. The search was conducted for longitudinal clinical trials comparing progression of peri-implantitis in IL-1 genotype positive (carrying allele 2) with IL-1 genotype negative (not carrying allele 2) subjects. Selection of publications, extraction of data and validity assessment were made independently by two reviewers.
Results:
The search provided 44 titles of which two longitudinal publications were included.
Conclusion:
Based on the findings from this study, there is not enough evidence to support or refute an association between the IL-1 genotype status and peri-implantitis. Systematic genetic testing for the assessment of the risk of peri-implantitis cannot be recommended as a standard of care at this time.
