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Related Experiment Video

Updated: Jun 28, 2026

Utero-tubal Embryo Transfer and Vasectomy in the Mouse Model
09:33

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Published on: February 28, 2014

Mouse exo utero development system: protocol and troubleshooting.

Makiko Yamada1, Toshihisa Hatta, Hiroki Otani

  • 1Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Japan.

Congenital Anomalies
|November 6, 2008
PubMed
Summary
This summary is machine-generated.

The novel mouse exo utero development system enables live embryo manipulation for functional analysis. This cost-effective method simplifies in vivo studies compared to genetic modification, advancing developmental science.

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Area of Science:

  • Developmental biology
  • Embryology
  • Reproductive science

Background:

  • Traditional in vivo studies often require genetically modified animal models.
  • Analyzing gene function or developmental processes in live embryos can be challenging.

Purpose of the Study:

  • To introduce and promote the use of the mouse exo utero development system.
  • To provide a detailed technical guide for researchers interested in this technique.

Main Methods:

  • The system allows for in situ manipulation of rodent embryos during mid- to late gestation.
  • Techniques include targeted injection of bioactive molecules or cells, lesioning, and fetal surgery.
  • Embryos are maintained alive ex utero for subsequent analysis.

Main Results:

  • The exo utero system offers a simpler, more time- and cost-effective alternative to generating transgenic animal lines.
  • It allows for precise experimental designs for studying embryonic development.
  • Detailed technical procedures, troubleshooting tips, and essential apparatus for fetal microinjection are elaborated.

Conclusions:

  • The mouse exo utero development system is a valuable tool for in vivo functional analysis in developmental biology.
  • It provides a flexible and efficient platform for investigating embryonic development and testing interventions.