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Antibiotic Selection00:57

Antibiotic Selection

Overview
Microbiota Modulation by Antibiotics01:21

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Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...
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A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
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A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
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Updated: Jun 28, 2026

Antibiotic Dereplication Using the Antibiotic Resistance Platform
10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

When antibiotics are unnecessary.

J V Hirschmann1

  • 1Medical Service (111), Puget Sound VA Medical Center, 1660 South Columbian Way, Seattle, WA 98108, USA. pepsi@u.washington.edu

Dermatologic Clinics
|November 6, 2008
PubMed
Summary
This summary is machine-generated.

Dermatologists can reduce unnecessary antimicrobial use by avoiding these agents when evidence shows they are ineffective. This includes certain skin conditions and prophylactic use in most surgical and high-risk patient scenarios.

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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Area of Science:

  • Dermatology
  • Infectious Disease
  • Pharmacology

Background:

  • Antimicrobial resistance is a growing global health concern.
  • Judicious use of antimicrobial agents in dermatology is crucial to combat resistance.
  • Evidence-based guidelines are needed to inform appropriate antimicrobial prescribing practices.

Purpose of the Study:

  • To identify dermatologic conditions and surgical scenarios where antimicrobial agents are ineffective or not indicated.
  • To provide evidence-based recommendations for decreasing unnecessary antimicrobial use in dermatology.
  • To inform dermatologists on appropriate antimicrobial stewardship.

Main Methods:

  • Review of controlled trials and clinical evidence regarding antimicrobial efficacy in dermatologic conditions.
  • Analysis of guidelines for prophylactic antibiotic use in dermatologic surgery and in patients with prosthetic devices or cardiac conditions.
  • Evaluation of topical antibiotic efficacy for wound care.

Main Results:

  • Antimicrobials are ineffective for cutaneous abscesses, inflamed epidermal cysts, uninfected atopic eczema, and uncomplicated diabetic or venous ulcers.
  • Prophylactic antibiotics are rarely indicated for routine dermatologic surgery and generally not for patients with prosthetic joints/grafts.
  • Topical antibiotics offer no benefit over white petrolatum for sutured wounds; moist dressings suffice.

Conclusions:

  • Dermatologists can significantly decrease unnecessary antimicrobial prescribing by adhering to evidence-based indications.
  • Avoiding antimicrobials in specific non-infectious dermatoses and for most prophylactic surgical uses is recommended.
  • Optimizing wound care with non-antibiotic options and appropriate dressing techniques is advised.