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Updated: Jun 28, 2026

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients
Published on: March 1, 2024
Involvement of nervous system pathways in primary Sjögren's syndrome
Barbara Segal1, Adam Carpenter, David Walk
1Division of Rheumatic and Autoimmune Disorders, University of Minnesota Medical School, MMC 108, 420 Delaware SE, Minneapolis, MN 55455, USA. segal017@umn.edu
Abstract:
A wide range of central and peripheral nervous system disorders occur in patients with primary Sjögren's syndrome (pSS), although the true prevalence is an aspect which has been and remains controversial. Under-recognition of pSS and lack of consensus regarding criteria contribute to the uncertainty regarding the extent of neuropsychiatric involvement. A relatively high rate of affective and cognitive symptoms, as well as abnormal fatigue and poorly characterized pain, are features of pSS that contribute to diminishing health quality in the pSS population. This article describes the neurologic complications and controversies that surround the neurologic syndromes associated with pSS and reviews the current literature on potential immunopathogenetic mechanisms and therapy.
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