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Related Concept Videos

Transmission of Pathogens01:24

Transmission of Pathogens

Pathogens spread from their reservoirs to susceptible hosts through three main routes: contact transmission, vehicle transmission, and vector transmission. Each route involves distinct mechanisms of transfer.Contact TransmissionThis category includes direct contact, indirect contact, and droplet transmission:Direct contact involves immediate physical interaction between individuals—such as a handshake—which can spread pathogens like Streptococcus pyogenes, the bacterium responsible for...
Infection01:20

Infection

When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...

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Related Experiment Video

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A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
13:56

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

Published on: July 18, 2013

PIG--the pathogen interaction gateway.

Tim Driscoll1, Matthew D Dyer, T M Murali

  • 1Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

Nucleic Acids Research
|November 6, 2008
PubMed
Summary
This summary is machine-generated.

This study introduces the Pathogen Interaction Gateway (PIG), a new resource for host-pathogen protein-protein interactions (PPIs). PIG integrates data to aid in understanding pathogen infection mechanisms and developing new therapeutics.

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High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions
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Area of Science:

  • Biochemistry
  • Bioinformatics
  • Pathogen Biology

Background:

  • Protein-protein interactions (PPIs) are crucial for pathogen infection processes.
  • Understanding host-pathogen interactions is key to developing novel therapeutics.
  • Existing public resources for host-pathogen PPI data are limited.

Purpose of the Study:

  • To create a centralized, integrated resource for host-pathogen PPI data.
  • To facilitate research into pathogen virulence mechanisms.
  • To provide tools for exploring and visualizing host-pathogen interactions.

Main Methods:

  • Integrated host-pathogen PPI data from multiple public resources.
  • Developed the Pathogen Interaction Gateway (PIG) database.
  • Implemented text-based search and BLAST functionalities within PIG.
  • Included functional annotations and domain information for interacting proteins.
  • Integrated links to external databases and network visualization tools.

Main Results:

  • The Pathogen Interaction Gateway (PIG) is now available.
  • PIG provides a searchable database of host-pathogen PPIs.
  • The resource includes detailed protein information and visualization capabilities.
  • Facilitates easier access and analysis of host-pathogen interaction data.

Conclusions:

  • The Pathogen Interaction Gateway (PIG) addresses the scarcity of public host-pathogen PPI resources.
  • PIG will aid researchers in understanding pathogenesis and identifying therapeutic targets.
  • The integrated data and tools in PIG support comprehensive study of host-pathogen interactions.