Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Addiction theory matters-Why there is no dependence on caffeine or antidepressant medication.

Addiction biology·2019
Same author

Pubertal maturation and sex effects on the default-mode network connectivity implicated in mood dysregulation.

Translational psychiatry·2019
Same author

Mental health in refugees and asylum seekers (MEHIRA): study design and methodology of a prospective multicentre randomized controlled trail investigating the effects of a stepped and collaborative care model.

European archives of psychiatry and clinical neuroscience·2019
Same author

The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study.

Cerebral cortex (New York, N.Y. : 1991)·2019
Same author

Correction: Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia.

Molecular psychiatry·2019
Same author

Reduced parietofrontal effective connectivity during a working-memory task in people with high delusional ideation

Journal of psychiatry & neuroscience : JPN·2019
Same journal

Major depressive disorder-alcohol use disorder comorbidity: diagnosis, mechanisms and treatment.

European archives of psychiatry and clinical neuroscience·2026
Same journal

The interplay between mental health, ecological factors, and problematic smartphone use: a network analysis in adolescents with major depressive disorder.

European archives of psychiatry and clinical neuroscience·2026
Same journal

The monocyte-to-HDL cholesterol ratio (MHR) modifies the association between dietary patterns and depression: a sex-specific analysis.

European archives of psychiatry and clinical neuroscience·2026
Same journal

Ictal electroencephalography and heart rate as treatment criteria in electroconvulsive therapy: a systematic review of the literature.

European archives of psychiatry and clinical neuroscience·2026
Same journal

Esketamine multi-omic biomarker evaluation in major depressive disorder (EMBER-MDD): concept, objectives and methodologies of a non-clinical investigator-initiated study.

European archives of psychiatry and clinical neuroscience·2026
Same journal

Differential burden of five major mental disorders in the United States across the COVID-19 pandemic.

European archives of psychiatry and clinical neuroscience·2026
See all related articles

Related Experiment Video

Updated: Jun 28, 2026

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
13:12

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

Imaging the deluded brain.

Astrid Knobel1, Andreas Heinz, Martin Voss

  • 1Department of Psychiatry and Psychotherapy, Charité Campus Mitte, Charitéplatz 1, Berlin, Germany.

European Archives of Psychiatry and Clinical Neuroscience
|December 5, 2008
PubMed
Summary
This summary is machine-generated.

Neuroimaging reveals temporo-limbic and frontal brain dysfunction, alongside dopamine dysregulation, contributing to delusions in schizophrenic psychoses. Cognitive biases in attribution and attention also play a role in delusion formation.

More Related Videos

An Experimental Protocol for Assessing the Performance of New Ultrasound Probes Based on CMUT Technology in Application to Brain Imaging
16:01

An Experimental Protocol for Assessing the Performance of New Ultrasound Probes Based on CMUT Technology in Application to Brain Imaging

Published on: September 24, 2017

3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol
10:14

3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol

Published on: May 12, 2019

Related Experiment Videos

Last Updated: Jun 28, 2026

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
13:12

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

An Experimental Protocol for Assessing the Performance of New Ultrasound Probes Based on CMUT Technology in Application to Brain Imaging
16:01

An Experimental Protocol for Assessing the Performance of New Ultrasound Probes Based on CMUT Technology in Application to Brain Imaging

Published on: September 24, 2017

3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol
10:14

3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol

Published on: May 12, 2019

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Delusions are a core feature of schizophrenic psychoses, influenced by various neurobiological and cognitive factors.
  • The neurodevelopmental hypothesis suggests early disruptions in temporo-limbic areas contribute to psychosis.
  • Previous functional and structural MRI studies have identified neurobiological correlates of paranoid symptoms.

Purpose of the Study:

  • To explore the neurobiological underpinnings of delusion formation in schizophrenic psychoses.
  • To investigate the role of temporo-limbic and frontal brain dysfunction in the development of delusions.
  • To examine the involvement of dopamine and cognitive biases in the maintenance of delusions.

Main Methods:

  • Review of functional and structural magnetic resonance imaging (fMRI and MRI) studies.
  • Analysis of neuroimaging data focusing on temporo-limbic and frontal brain regions.
  • Examination of the role of dopamine neuromodulation and cognitive processes (attributional and attentional biases).

Main Results:

  • Neuroimaging studies indicate significant temporo-limbic and frontal dysfunction associated with delusion formation.
  • Evidence supports the involvement of disinhibited striatal dopamine release, consistent with the neurodevelopmental hypothesis.
  • Cognitive biases, including attributional and attentional biases for affective stimuli, are implicated in delusion maintenance.

Conclusions:

  • Delusion formation in schizophrenia is linked to dysfunction in temporo-limbic and frontal brain areas.
  • Dopamine plays a crucial neuromodulatory role in the development and maintenance of delusions.
  • Cognitive processes, such as attributional and attentional biases, are integral to understanding delusion formation.