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Updated: Jun 28, 2026

Retropinacol/Cross-pinacol Coupling Reactions - A Catalytic Access to 1,2-Unsymmetrical Diols
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Published on: April 4, 2014

Iron-catalyzed enyne cross-coupling reaction.

Takuji Hatakeyama1, Yuya Yoshimoto, Toma Gabriel

  • 1International Research Center for Elements Science, Institute for Chemical Research, Kyoto University, Uji, Kyoto, 611-0011, Japan.

Organic Letters
|November 7, 2008
PubMed
Summary

This study introduces a new method for synthesizing conjugated enynes using alkynyl Grignard reagents and alkenyl electrophiles. The reaction is catalyzed by iron(III) chloride and a lithium bromide additive, achieving high yields.

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