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Related Experiment Videos

Recurrence after radiotherapy for glottic carcinoma.

L Viani1, P M Stell, J E Dalby

  • 1Department of Otorhinolaryngology, University of Liverpool, England.

Cancer
|February 1, 1991
PubMed
Summary
This summary is machine-generated.

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This study on glottic carcinoma treated with irradiation found a 10% primary recurrence rate. Recurrence risk increased with tumor stage and poor differentiation, impacting survival and treatment options.

Area of Science:

  • Oncology
  • Radiation Oncology
  • Head and Neck Surgery

Background:

  • Glottic carcinoma is a common head and neck cancer.
  • Irradiation is a primary treatment modality for early-stage glottic cancer.
  • Understanding recurrence patterns is crucial for optimizing treatment and improving patient outcomes.

Purpose of the Study:

  • To analyze the recurrence patterns and survival outcomes in patients with T1-3N0 glottic carcinoma treated with irradiation.
  • To identify prognostic factors for primary recurrence and lymph node metastasis.
  • To evaluate the impact of recurrence on laryngeal preservation and overall survival.

Main Methods:

  • Retrospective analysis of 478 patients with T1-3N0 glottic carcinoma treated with irradiation.
  • Inclusion of both previously untreated patients and those treated for recurrence.

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  • Detailed follow-up to assess recurrence rates, sites, survival, and treatment complications.

    • Main Results:

    • A 10% primary recurrence rate was observed in previously untreated patients, higher in advanced T stages and poorly differentiated tumors.
    • Recurrent tumors were often advanced (pT3/pT4), with 60% being transglottic.
    • Five-year survival after primary recurrence was 39%, with lymph node metastasis being a common cause of death.
    • Lymph node recurrence occurred in 14% of patients, with advanced T stage and poor general condition as predictors.
    • Survival after node recurrence was 16%, with uncontrolled neck disease as the primary cause of death.

    Conclusions:

    • Irradiation for T1-3N0 glottic carcinoma has a significant recurrence rate, particularly for advanced or poorly differentiated tumors.
    • Recurrence often leads to advanced disease, impacting laryngeal preservation and survival.
    • Timely diagnosis and management of recurrence, including lymph node metastasis, are critical for improving outcomes.
    • Histologic confirmation of recurrence is essential, as negative reports may be unreliable.