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Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery
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Lead extraction: a new effective tool to overcome fibrous binding sites

Antonio Dello Russo1, Roberto Biddau, Gemma Pelargonio

  • 1Cardiac Arrhythmia and Heart Failure Research Center, Catholic University of Sacred Heart - St. Camillo-Forlanini Hospital, Rome, Italy.

Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing
|November 7, 2008
PubMed

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Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is formed in...
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