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11:49
Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
Published on: May 2, 2013
Long-term trend in patch test reactions: a 32-year statistical overview (1970-2002), part II
Emilie Tudela1, Cora MacPherson, Howard I Maibach
1University of California San Francisco Medical School, Department of Dermatology, San Francisco, California, USA. etudela-lopez@chu-grenoble.fr
Cutaneous and Ocular Toxicology
|November 7, 2008
Summary
Allergic contact dermatitis trends show increasing reactions to certain chemicals like carbamates and formaldehyde, while others remained stable or decreased. Public health efforts are needed to reduce this common skin condition.
Area of Science:
- Dermatology
- Epidemiology
- Toxicology
Background:
- Allergic contact dermatitis (ACD) is a significant global health issue.
- Understanding trends in patch test positivity is crucial for managing ACD.
- The North American Contact Dermatitis Group (NACDG) provides valuable data on allergen prevalence.
Purpose of the Study:
- To analyze trends in patch test positivity for common allergens over a 32-year period.
- To identify specific allergens associated with increasing, decreasing, or stable rates of allergic reactions.
- To inform public health strategies for mitigating allergic contact dermatitis.
Main Methods:
- Review and re-analysis of NACDG publications from 1970 to 2002.
- Statistical analysis using the Cochran-Armitage trend test to determine significance.
- Examination of patch test results for a comprehensive list of allergens.
Main Results:
- Significant increases in positive patch test reactions observed for carbamates, balsam of Peru, thimerosal, formaldehyde, imidazolidinyl urea, and methyldibromoglutaronitrile.
- Stable rates of positive reactions noted for Dimethylol dimethyl (DMDM) hydantoin, diazolidinyl urea, and methylchloroisothiazolone/methylisothiazolone.
- Significant decreases in positive reactions reported for all other analyzed allergens.
Conclusions:
- The study highlights evolving patterns in allergic contact dermatitis, with specific allergens showing concerning upward trends.
- Findings present public health challenges for industry, government, and medical professionals in reducing ACD.
- Data interpretation requires caution due to the complexity of a 32-year analysis and should be considered within the study's context.
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