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Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
Published on: July 8, 2025
Post stroke seizures: descriptive study from a tertiary care centre in Pakistan
Bhojo A Khealani1, Sajjad Ali, Shahid M Baig
1Department of Medicine, Aga Khan University Hospital, Karachi.
JPMA. the Journal of the Pakistan Medical Association
|November 8, 2008
Summary
Post-stroke seizures occur in 8% of stroke patients, being more common after ischemic stroke. Systemic infections early in the course are linked to recurrent seizures at one year.
Area of Science:
- Neurology
- Stroke Medicine
- Epileptology
Background:
- Post-stroke seizures (PSS) are a significant complication following cerebrovascular events.
- Understanding the incidence, characteristics, and predictors of PSS is crucial for patient management.
Purpose of the Study:
- To investigate the frequency, onset patterns, and outcomes of seizures occurring after stroke in a specific geographic region.
- To identify factors associated with the development and recurrence of post-stroke seizures.
Main Methods:
- A combined retrospective and prospective study design was employed over a three-year period.
- Data from 1548 stroke patients admitted to a tertiary care center were analyzed, including demographic, clinical, and outcome variables.
- Specific focus was placed on patients who developed seizures post-stroke, examining seizure type, timing, and one-year follow-up outcomes.
Main Results:
- The overall incidence of seizures among stroke patients was 8% (117/1548).
- Seizures were more frequent in patients with ischemic stroke (9%) compared to intracerebral hemorrhage (5%).
- Most seizures occurred after 14 days (92%), with generalized seizures being more common (78%) than partial seizures (22%). Systemic infections early in the stroke course were associated with a higher rate of seizure recurrence at one year (40% vs 11%).
Conclusions:
- The frequency of post-stroke seizures in this population aligns with findings from Western literature.
- Ischemic stroke and early systemic infections are significant factors associated with post-stroke seizures and their recurrence.
- Generalized seizures are the predominant type observed in the post-stroke period.
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