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Post stroke seizures: descriptive study from a tertiary care centre in Pakistan

Bhojo A Khealani1, Sajjad Ali, Shahid M Baig

  • 1Department of Medicine, Aga Khan University Hospital, Karachi.

JPMA. the Journal of the Pakistan Medical Association
|November 8, 2008
PubMed

Insights

Post-stroke seizures occur in 8% of stroke patients, being more common after ischemic stroke. Systemic infections early in the course are linked to recurrent seizures at one year.

Area of Science:

  • Neurology
  • Stroke Medicine
  • Epileptology

Background:

  • Post-stroke seizures (PSS) are a significant complication following cerebrovascular events.
  • Understanding the incidence, characteristics, and predictors of PSS is crucial for patient management.

Purpose of the Study:

  • To investigate the frequency, onset patterns, and outcomes of seizures occurring after stroke in a specific geographic region.
  • To identify factors associated with the development and recurrence of post-stroke seizures.

Main Methods:

  • A combined retrospective and prospective study design was employed over a three-year period.
  • Data from 1548 stroke patients admitted to a tertiary care center were analyzed, including demographic, clinical, and outcome variables.
  • Specific focus was placed on patients who developed seizures post-stroke, examining seizure type, timing, and one-year follow-up outcomes.

Main Results:

  • The overall incidence of seizures among stroke patients was 8% (117/1548).
  • Seizures were more frequent in patients with ischemic stroke (9%) compared to intracerebral hemorrhage (5%).
  • Most seizures occurred after 14 days (92%), with generalized seizures being more common (78%) than partial seizures (22%). Systemic infections early in the stroke course were associated with a higher rate of seizure recurrence at one year (40% vs 11%).

Conclusions:

  • The frequency of post-stroke seizures in this population aligns with findings from Western literature.
  • Ischemic stroke and early systemic infections are significant factors associated with post-stroke seizures and their recurrence.
  • Generalized seizures are the predominant type observed in the post-stroke period.
Abstract

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