Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Families02:47

Protein Families

Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key locations, protein...
Gene Families01:57

Gene Families

Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
Globular and Fibrous Proteins02:21

Globular and Fibrous Proteins

Many proteins can be classified into two distinct subtypes - globular or fibrous. These two types differ in their shapes and solubilities.
Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DLK1 is a GATA1s-driven dependency and therapeutic target in Down syndrome-associated myeloid leukemia.

Blood advances·2026
Same author

Early Unloading After ACL Rupture and Prior to Surgical Restabilization in Mice Slows Post-Traumatic Osteoarthritis Progression.

Cartilage·2026
Same author

Single cell RNA sequencing reveals shifts in cell maturity and function of endogenous and infiltrating cell types in response to acute intervertebral disc injury.

Experimental cell research·2025
Same author

Early immune response to <i>Coccidioides</i> is characterized by robust neutrophil and fibrotic macrophage recruitment and differentiation.

Microbiology spectrum·2025
Same author

Direct effects of prolonged TNF-α and IL-6 exposure on neural activity in human iPSC-derived neuron-astrocyte co-cultures.

Frontiers in cellular neuroscience·2025
Same author

Single-cell and spatiotemporal transcriptomic profiling of brain immune infiltration following Venezuelan equine encephalitis virus infection.

Frontiers in immunology·2025
Same journal

Correction to 'scSuperAnnotator: A platform for benchmarking comparison and visualizing automated cellular annotation methods for scRNA-seq data'.

Nucleic acids research·2026
Same journal

Correction to 'Differentiable partition function calculation for RNA'.

Nucleic acids research·2026
Same journal

Deployment of non-canonical splicing in tunicate genomes is mediated by divergent U2AF function and changing m6A modification in U1 and U6 snRNA.

Nucleic acids research·2026
Same journal

Bacillus subtilis DnaB forms multiple protein-protein interactions essential for DNA replication initiation.

Nucleic acids research·2026
Same journal

Multiple forms of protein-protein and DNA binding are exhibited by BrxC from the BREX phage restriction system.

Nucleic acids research·2026
Same journal

Biosynthesis of glycosylated 5-hydroxycytosine in the DNA of diverse viruses.

Nucleic acids research·2026
See all related articles

Related Experiment Video

Updated: Jun 28, 2026

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
09:10

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

Human Protein Reference Database--2009 update.

T S Keshava Prasad1, Renu Goel, Kumaran Kandasamy

  • 1Institute of Bioinformatics, International Tech Park, Bangalore 560 066, India.

Nucleic Acids Research
|November 8, 2008
PubMed
Summary
This summary is machine-generated.

The Human Protein Reference Database (HPRD) now includes PhosphoMotif Finder and Human Proteinpedia, enhancing proteomic data analysis. These updates provide comprehensive human proteome information and signaling pathway insights.

More Related Videos

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

Related Experiment Videos

Last Updated: Jun 28, 2026

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
09:10

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

Area of Science:

  • Proteomics
  • Bioinformatics
  • Molecular Biology

Background:

  • The Human Protein Reference Database (HPRD) has been a key resource for curated human protein information since 2003.
  • Ongoing advancements in proteomics necessitate continuous updates and expansion of protein databases.

Purpose of the Study:

  • To introduce new features and data into HPRD, enhancing its utility for researchers.
  • To expand the scope of HPRD by integrating diverse proteomic datasets and signaling pathway information.

Main Methods:

  • Integration of PhosphoMotif Finder for identifying phosphorylation motifs.
  • Implementation of Human Proteinpedia, a distributed annotation system for collaborative data submission.
  • Linking HPRD with NetPath, a compendium of human signaling pathways.
  • Addition of over 5500 new human protein sequences.

Main Results:

  • HPRD now features PhosphoMotif Finder with over 320 experimentally verified motifs.
  • Human Proteinpedia has contributions from over 75 laboratories, covering more than 15,000 human proteins.
  • Data types include mass spectrometry and protein microarray results.
  • NetPath compendium includes annotations for cancer and immune signaling pathways.

Conclusions:

  • HPRD has been significantly enhanced with new tools and expanded data, offering a more comprehensive resource.
  • The collaborative nature of Human Proteinpedia and the integration of NetPath improve the depth and breadth of human proteome research.
  • These updates solidify HPRD's role as a vital resource for studying the human proteome and its associated signaling pathways.