Circulating carbon monoxide level is elevated after sleep in patients with obstructive sleep apnea
Masayoshi Kobayashi1, Naoki Miyazawa1, Mitsuhiro Takeno1
1Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Chest
|November 8, 2008
Summary
Morning carbon monoxide (CO) levels are elevated in obstructive sleep apnea (OSA) patients and correlate with disease severity. Continuous positive airway pressure (CPAP) treatment normalizes these levels, potentially reducing cardiovascular event risk.
Area of Science:
- Cardiovascular Medicine
- Sleep Medicine
- Biochemistry
Background:
- Obstructive sleep apnea (OSA) is linked to increased cardiovascular morbidity.
- Circulating carbon monoxide (CO) is a potential biomarker for cardiovascular risk in OSA.
Purpose of the Study:
- To investigate circulating CO levels as a marker of cardiovascular risk in OSA patients.
- To assess the impact of continuous positive airway pressure (CPAP) on CO levels in OSA.
Main Methods:
- Venous blood samples collected from 35 OSA patients and 17 controls before and after polysomnography.
- Quantification of venous CO and serum heme oxygenase (HO)-1 using gas chromatography and ELISA, respectively.
Main Results:
- Morning CO levels were significantly higher in OSA patients compared to controls.
- The increase in CO levels correlated with apnea-hypopnea index and hypoxia duration.
- Serum HO-1 levels did not differ between groups.
- CPAP treatment normalized postsleep CO levels in OSA patients.
Conclusions:
- Postsleep circulating CO levels can help assess OSA clinical severity.
- CPAP treatment for OSA may mitigate the risk of associated cardiovascular events.
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