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Decrease in luteal gonadotropin concentration in conception cycles after in vitro fertilization/gamete intrafallopian

R J Norman1, G M Warnes, S Segal

  • 1Reproductive Medicine Unit, Queen Elizabeth Hospital, Woodville, South Australia.

Fertility and Sterility
|January 1, 1991
PubMed
Summary
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In ovarian hyperstimulation cycles, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels differ between conception and non-conception. Pregnancy is associated with suppressed gonadotropins, likely due to rising estradiol and progesterone.

Area of Science:

  • Reproductive Endocrinology
  • Infertility Treatment
  • Hormonal Regulation

Background:

  • Ovarian hyperstimulation involves complex hormonal changes.
  • Gonadotropin levels (LH, FSH) play a crucial role in the menstrual cycle and early pregnancy.

Purpose of the Study:

  • To investigate luteinizing hormone (LH) and follicle-stimulating hormone (FSH) concentrations during the luteal phase in patients undergoing ovarian hyperstimulation.
  • To compare gonadotropin levels in conception versus non-conception cycles.
  • To explore the relationship between estradiol, progesterone, and gonadotropin levels in pregnancy.

Main Methods:

  • Measurement of LH and FSH concentrations in the luteal phase of ovarian hyperstimulation cycles.
  • Comparison of hormone levels between conception and non-conception cycles.

Related Experiment Videos

  • Analysis of hormone levels in singleton conception, twin pregnancy, and spontaneous abortion groups.

    • Main Results:

    • In non-conception cycles, LH and FSH were elevated in the late luteal phase compared to conception cycles.
    • Conception cycles showed suppressed LH and FSH.
    • Estradiol (E2) and progesterone increases in pregnancy cycles correlated with gonadotropin suppression; LH and FSH levels were equivalent when E2 concentrations were matched.
    • No significant LH/FSH differences were found between singleton conception, twin pregnancy, or spontaneous abortion groups, though FSH tended to be lower in twin pregnancies.

    Conclusions:

    • Suppression of LH and FSH in hyperstimulated pregnancy cycles occurs after the rise in human chorionic gonadotropin (hCG).
    • Estradiol and progesterone likely mediate gonadotropin suppression in early pregnancy following ovarian hyperstimulation.