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Updated: Jun 28, 2026

High-Throughput Expression and Purification of Human Solute Carriers for Structural and Biochemical Studies
Published on: September 29, 2023
Technologies for transporter drug discovery
Adam B Weinglass1, Maria L Garcia, Gregory L Kaczorowski
1Merck Research Laboratories, Department of Ion Channels, Rahway, New Jersey 07065, USA. adam_weinglass@merck.com
Abstract:
Transporters represent attractive targets for drug discovery and are implicated in the pathophysiology of disorders across several therapeutic areas including asthma, cardiovascular disease, diabetes and neuroscience. However, the intrinsic mechanistic properties of transporters present significant challenges to the development of high-throughput screening methodologies. This review provides an update on potential transporter targets and evaluates the impact of available technologies to enable transporter screening, lead optimization and assessment of pharmacokinetics.
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